Hormone Therapy

Initiating Male Hormone Therapy in Gender Dysphoria Management

Upon the diagnosis of Gender Dysphoria (GD) or identification as a transgender individual desiring to live and be recognized in a male role, the commencement of male hormone therapy marks a significant phase in both non-surgical and surgical gender reassignment paths.

This treatment aims to induce physical changes aligning with a male presentation, facilitating the individual’s journey towards a more congruent self-identity.

Role of Male Hormone Therapy

Male hormone therapy, often the first line of treatment for those seeking gender transition, endeavors to modify the body to exhibit more masculine characteristics.

Visible results may become apparent within a timeframe of six months or more, allowing individuals to deliberate on their affinity for continued treatment, the extent of desired physical modification, or the cessation of hormone therapy if it does not align with their expectations. Importantly, male hormone therapy can be reversible, permitting fertility restoration.

Multidisciplinary Approach to Treatment

The treatment process necessitates collaboration among various specialists, including psychiatrists and gynecologists, to assess the appropriateness of hormone therapy for each patient. Patients often encounter a gynecologist initially, sometimes before seeing a psychiatrist, due to a lack of understanding of the necessary procedural steps.

Gynecologists, specializing in the female reproductive system and hormonal treatments, play a crucial role in evaluating the suitability of initiating male hormone therapy.

Considerations Prior to Hormone Therapy

Before the administration of male hormones, a comprehensive evaluation to discern the patient’s genuine desires and the outcomes they anticipate from transitioning is paramount. Misguided self-prescription, influenced by social media or peer recommendations, poses significant risks.

Male hormones, potent substances capable of profound physiological changes, should be administered under professional guidance to mitigate adverse effects and ensure compatibility with the individual’s health status.

The Procedure of Male Hormone Therapy

Administered in various forms, including injections, oral medications, and gels, male hormone therapy’s primary aim is to suppress female hormonal activity while promoting masculinizing effects.

These effects range from alterations in body fat distribution and muscle mass to changes in hair growth patterns and voice pitch. The method of hormone delivery is selected based on patient preference, with considerations for the duration of effect, ease of dosage adjustment, and potential side effects.

Permanent and Reversible Changes Induced by Therapy

The therapy brings about both irreversible and reversible changes, with some modifications such as voice deepening and hair growth patterns remaining permanent even after the cessation of hormone therapy.

Conversely, aspects like fertility may be restored upon discontinuing hormone use, emphasizing the importance of informed decision-making in the therapy process.

Monitoring and Side Effects

Ongoing monitoring by healthcare professionals is crucial to address potential side effects, including polycythemia, high blood pressure, and changes in lipid profiles.

These risks underscore the necessity of a tailored approach to hormone therapy, balancing the desired masculinizing effects with the individual’s overall health and well-being.


Male hormone therapy represents a foundational aspect of the gender transition process for individuals with GD, offering the possibility of aligning one’s physical appearance with their gender identity.

The decision to undergo hormone therapy should be made with thorough consideration of the potential physical changes, both permanent and reversible, and under the guidance of experienced medical professionals to ensure a safe and effective treatment plan.

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